Interferon- gamma-induced protein-10 (IP-10) serum level and natural killer cell count as predictive factors for the severity of COVID-19

Background: The immune mechanisms underlying the pathology of COVID-19 are currently under immense scrutiny. Following NK and T cell activation, a surge proinflammatory cytokines, chemokines such IP-10, found to increase. These cytokines stimulate adaptive response recruit other cells site infection. Paradoxically, known be decreased in peripheral circulation severely ill COVID patients. It is not clear if this decrease number due depletion or recruitment sites inflammation. purpose study was determine there correlation between IP-10 levels numbers correlates with diseases severity. Methods: involved 30 patients divided into 2 groups (moderate severe) depending on disease severity, as well 15 age- gender-matched controls. Serum were assessed by ELISA determination determined flow cytometry. Results: results demonstrate an inverse relationship levels. Moreover, characteristically displayed increased serum manner that Conclusion:  The severity associated production which may tissues lung, partially explain severe pathology.